Running decreases knee intra-articular cytokine and cartilage oligomeric matrix concentrations: a pilot study
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© 2017 Springer International Publishing AG. Part of Springer Nature.
Regular exercise protects against degenerative joint disorders, yet the mechanisms that underlie these benefits are poorly understood. Chronic, low-grade inflammation is widely implicated in the onset and progression of degenerative joint disease.
To examine the effect of running on knee intra-articular and circulating markers of inflammation and cartilage turnover in healthy men and women.
Running appears to decrease knee intra-articular pro-inflammatory cytokine concentration and facilitates the movement of COMP from the joint space to the serum.
Biomarker; COMP; Exercise; GM-CSF; Ground reaction force; IL-15; IL-6; Inflammation; Knee joint; Osteoarthritis; Synovial fluid
- PMID: 27699484 DOI: 10.1007/s00421-016-3474-z
- [PubMed – in process]